Cancer, malignant tumour

Cancer is an umbrella term for many malignant growths that can destroy healthy, well-functioning tissue.

1 May 2021 | 5 Min. Reading Time

Overview

Cancer is an umbrella term for many malignant growths that can destroy healthy, well-functioning tissue. Unfortunately, without treatment the disease often ends in death. The earlier a tumour is detected and treated, the better the chances for a complete recovery. Symptoms vary greatly, depending on the affected organ system.

This chapter gives an overview. For more detailed information, please consult the entries for the individual types of cancer.

Symptoms

Characteristics of cancer
- Invasive/infiltrating, expansile or locally destructive
- Formation of metastases
- The first symptoms often aren't early-stage symptoms (the tumour can already be quite advanced)
A complete list of organ-specific symptoms can't be provided here, but some typical examples include:
- Lumps or hardening in the breast (breast cancer)
- Coughing blood, repeated bronchitis attacks or pneumonia (lung cancer)
- Loss of appetite, sudden aversion to some foods (stomach cancer)
- Changes to bowel habits or bleeding from the anus (bowel cancer)
- Jaundice (pancreatic or liver cancer)
- Swollen lymph nodes and increased susceptibility to infections (lymph node cancer and leukaemia)
- Bloody urine (kidney cancer, bladder cancer)
Common signs of advanced or end-stage cancer include:
- Loss of appetite, massive weight loss
- Fatigue, paleness, anaemia
- Fever, tendency to bleed
- Night sweats (pyjamas are wet with sweat)
- Pain, neurological deficits, etc.

Causes and treatment

Causes

Degeneration of cells
- Damage/change to DNA
- The body normally eliminates the damaged cells, but if it doesn’t...
- The defect is passed on and the cells continue to multiply unchecked
Genetic factors: family history of cancer
Hormones: sex hormones stimulate the growth of malignant tumours in the breast, ovaries or prostate
Certain oncogenic viruses (e.g. HPV, EBV, CMV, hepatitis B)
UV radiation, sunlight
Radiation exposure
Chronic infections and irritations (e.g. cigarettes or excessive consumption of alcohol )
Harmful chemicals (e.g. organic solvents, tar, heavy metals, asbestos)

Cell type

Carcinoma: originates in epithelial cells (that line the surfaces of the body)
- Examples: intestinal mucosa (bowel cancer), skin cancer, breast cancer, bronchial carcinoma (lung cancer)
Sarcoma: originates in the connective tissue or the specialised tissue of internal organs
- Examples: osteosarcoma (bone tumour), liposarcoma (fatty tissue)

Further treatment by your doctor / in hospital

Possible tests

Blood test
Imaging procedures
- X-ray
- Ultrasound
- CT scan (computed tomography)
- MRI (magnetic resonance imaging)
Imaging of internal organs
- Direct view of problem area
- Removal of tissue samples (pathological analysis)

Possible therapies

Objectives:
- Curative approach: the objective is to cure the disease
- Palliative approach: the objective is to provide relief and improve the quality of life and the outcome
Methods:
- Operation
- Radiation therapy
- Chemotherapy
- Hormone or immune therapy

What can I do myself?

Stop smoking
Sun protection
Develop awareness of physical (warning) signs
Regular self-examination (in particular skin, breasts, testicles)
Inform doctor of personal risk factors
- Frequent occurrence of specific tumours in close relatives
- Smoking, chronic alcohol abuse
- Professional exposure (chemicals, radiation, asbestos)

When to see a doctor?

Unexplained weight loss
Unexplained fever over a longer period
Night sweats (pyjamas are wet with sweat)
Coughing blood
Blood in stools or urine
Palpable lumps or hardening
Early detection improves the chances of healing
- If you suspect cancer, don’t postpone/avoid a consultation with a doctor
- Regular preventive gynaecological examinations
- Prostate examinations from age 50, from age 45 if at higher risk